SSAA09E1
SARS-CoV viral entry inhibitor / SSAA09E1 (433212-75-0) is an inhibitor of SARS coronavirus (SARS-CoV) replication by blocking viral entry (EC50=6.7mM). SSAA09E1 was discovered by screening a chemical library for blocking of entry of HIV-1 pseudotyped with SARS-CoV surface glycoprotein S. The compound acts via inhibition of cathepsin L(IC50=5.33 mM), a host protease required for processing of SARS-S during viral entry. Cathepsin B is not inhibited.1 The compound was also shown to inhibit tyrosinase (IC50=0.14 mM).2
Biochemicals & reagents
433212-75-0
1 Adedeji et al., (2013) Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms; J. Virol. 87 8017 2 Liu et al., (2008) 1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors; Bioorg. Med. Chem. 16 1096
-20°C
TARGET: Protease -- DISEASE AREA: Infectious disease