Bromotetramisole, L-(-) oxalate
Alkaline phosphatase inhibitor / Potent alkaline phosphatase inhibitor.1 Strongly activates cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels by inhibiting a membrane associated protein phosphatase.2 Inhibits terminal cell division-associated differentiation in murine erythroleukemia cells.3
Biochemicals & reagents
62284-79-1
L-p-Bromotetramisole oxalate; (-)-p-Bromolevamisole
1) Kovach et al. (1992), Levamisole potentiation of fluorouracil antiproliferative activity mimicked by orthovanadate, an inhibitor of tyrosine phosphatase; J. Natl. Cancer Inst., 84 515 2) Luo et al. (2000), Role of protein phosphatases in the activation of CTFR (ABCC7) by genistein and bromotetramisole Am. J. Physiol. Cell Physiol., 279 C108 3) Scher et al. (1998), The phosphatase inhibitors, orthovanadate and levamisole, inhibit induction of erythroid differentiation and abrogate the associated inhibition of glycolysis; Int. J. Oncol., 12 987
RT
TARGET: Phosphatase -- PATHWAY: Chloride channel -- RESEARCH AREA: Angiogenesis