EN450
Supplier:
Catalogue number:
10-3936-02
Size:
25 mg
Product is available in:
NFkB1 molecular glue / EN450 is a molecular glue that covalently interacts with a cysteine residue on the E2 ubiquitin ligase UBE2D. It displayed anti-proliferative effects in HAP1 leukemia cells. EN450s antiproliferative effects were elicited via proteasome-dependent degradation of nuclear factor kappa B subunit 1(NFkB1).1
Product Type:
Biochemicals & reagents
CAS Number:
793719-01-4
Alternative Names:
N-[2-Chloro-5-(dimethylsulfamoyl)phenyl]prop-2-enamide
Reference:
King et al. (2023), Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-kB; Cell Chem. Biol. 30 394
Storage Temperature:
-20°C
Additional Information:
TARGET: Molecular glue -- PATHWAY: NFkappaB; Proliferation; Degradation -- RESEARCH AREA: Ubiquitin/Proteasome -- DISEASE AREA: Cancer