Enhances mitochondrial fusion / Enhances mitochondrial fusion without interfering with endoplasmic reticulum (ER) and lysosome morphology.1 M-1 protects cells from mitochondrial fragmentation-associated cell death.2 Promotion of mitochondrial fusion has protective effects in rotenone-induced neurotoxicity.3 Cell permeable.
Biochemicals & reagents
219315-22-7
1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone
1) Andreaux et al. (2013), Pharmacological approaches to restore mitochondrial function; Nature Rev. Drug Disc., 12 465 2) Yang et al. (2015), Mitochondrial fusion provides an ‘initial metabolic complementation’ controlled by mtDNA; Cell Mol. Life Sci., 72 2585 3) Peng et al. (2017), The interaction of mitochondrial Biogenesis and Fission/Fusion Mediated b PGC-1a Regulates Rotenone-Induced Dopaminergic Neurotoxicity; Mol. Neurobiol., 54 3783
RT
TARGET: Lysosome -- PATHWAY: Mitochondrial function -- RESEARCH AREA: Neuroscience; Cell death; Vesicles