ABX-1431
Supplier:
Catalogue number:
10-4596-01
Size:
10 mg
Product is available in:
MAGL inhibitor / Potent (IC50 = 14 nM in vitro, 2.2 nM in human PC3 cells) and very selective (>100-fold over hABHD6, >200-fold over hPLA2G7) inhibitor of monoacylglycerol lipase (MAGL).1 Active in a rat formalin pain test at 3mg/kg. Orally bioavailable and CNS penetrant.
Product Type:
Biochemicals & reagents
CAS Number:
1446817-84-0
Reference:
Cisar et al. (2018), Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders; J. Med. Chem., 61 9062
Storage Temperature:
-20°C
Additional Information:
TARGET: Lipase -- PATHWAY: Fatty acid metabolism; Lipid signaling -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Pain; InflammationNeurodegeneration