Orlistat
DAG Lipase-α inhibitor / A lipase inhibitor which blocks the biosynthesis of 2-AG by inhibition of DAG lipase-α1. Inhibits pancreatic lipase and other lipases but not PLA22. Inhibits fatty acid synthase and displays antitumor activity3. Prevents fat absorption in the gut and is a clinically useful antiobesity agent4.
Biochemicals & reagents
96829-58-2
Ro18-0647; (-)-Tetrahydrolipstatin
1) Bisogno et al. (2006), Development of the first potent and specific inhibitors of endocannabinoid biosynthesis; Biochim. Biophys. Acta, 1761 205 2) Hadvary et al. (1991), The lipase inhibitor tetrahydrolipstatin bind covalently to the putative active site serine of pancreatic lipase; J. Biol. Chem., 266 2021 3) Kridel et al. (2004), Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity; Cancer Res., 64 2070 4) Ballinger & Peikin (2002), Orlistat: it’s current status as an anti-obesity drug; Eur. J. Pharmacol., 440 109
-20°C
TARGET: Lipase -- PATHWAY: Fatty acid metabolism -- DISEASE AREA: Cancer; ObesityDiabetes