Chroman 1
ROCK II inhibitor / Stem cell cytoprotectant / Extremely potent inhibitor of Rho kinase II (ROCK-II)1,2 – it displayed greater selectivity and potency compared to Y-27632 (IC50’s: ROCK I = 52 pM/ROCK II = 1 pM; Y-27632 IC50’s: ROCK I = 71 nM/ROCK II = 46 nM)3. Chroman 1, used in conjunction with trans-ISRIB (Cat# 10-1539), Emricasan (Cat# 10-4280), and polyamines (CEPT cocktail), promotes cytoprotective cell survival in human pluripotent stem cells (hPSCs) and was found to superior to Y-27632.3 Chroman 1 is an important new tool in the generation and maintenance of stem cells.
Biochemicals & reagents
1273579-40-0
1) Chen et al. (2011), Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors; Med. Chem. Commun.,2 73 2) Chen et al. (2008), Chroman-3-amides as potent Rho kinase inhibitors; Bioorg. Med. Chem. Lett., 18 6406 3) Chen et al. (2021), A Versatile Polypharmacology Platform Promotes Cytoprotection and Viability of Human Pluripotent and Differentiated Cells; Nat. Methods, 18 528
-20°C
TARGET: Kinase -- RESEARCH AREA: Stem cells