HA-100 2HCl
Multi-kinase inhibitor / Inhibits the following kinases PKG (IC50=4 mM), PKA (IC50=8 mM), PKC (IC50=12 mM).1 Increases human fibroblast reprogramming efficiency with PD0325901, CHIR99021, A83-01 and hLIF.2 Improves single cell survival and supports high cloning efficiency in human pluripotent stem cells.3
Biochemicals & reagents
84468-24-6
1 Hagiwara et al. (1987), Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives; Pharmacol., 32 7 2 Yu et al. (2011), Efficient feeder-free episomal reprogramming with small molecules; PLoS One, 6(3) e17557 3 Chen et al. (2011), Chemically defined conditions for human iPSC derivation and culture; Nature Methods, 8 424
-20°C
TARGET: Kinase -- PATHWAY: cAMP / cGMP signaling -- RESEARCH AREA: Stem cells