JNK inhibitor IX
Supplier:
Catalogue number:
10-1528-02
Size:
25 mg
Product is available in:
JNK inhibitor / Inhibits JNK2 and JNK3 via binding to the ATP binding domain. Displays little or no activity against JNK1, p38α and a panel of 30 other kinases.1 Induces prometaphase arrest-dependent apoptotic cell death in human Jurkat T cells.2
Product Type:
Biochemicals & reagents
CAS Number:
312917-14-9
Alternative Names:
TCS JNK 5a
Reference:
1) Angell et al. (2007), N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3; Med. Chem. Lett., 17 1296 2) Jang et al. (2014), Inhibition of JNK2 and JNK3 by JNK inhibitor IX induces prometaphase arrest-dependent apoptotic cell death in human Jurkat T cells ; Biochem. Biophys. Res. Commun., 452 845
Storage Temperature:
RT
Additional Information:
TARGET: Kinase -- PATHWAY: Apoptosis inducer; JNK pathway -- RESEARCH AREA: Cell death