AG-1296
PDGFR kinase inhibitor / Potent inhibitor of PDGF receptor kinase (IC50 = 1 µM), c-kit and FGF kinase. Induces apoptosis in H526, small-cell lung cancer cells.
Biochemicals & reagents
146535-11-7
1) Kovalenko et al. (1997), Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296; Biochemistry, 36 6260 / 2) Krystal et al. (1997), Induction of apoptosis and inhibition of small cell lung cancer growth by the quinoxaline tyrphostins; Cancer Res., 57 2203 / 3) Strutz et al. (2001), TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2); Kidney Int., 59 579
-20°C
TARGET: Kinase -- PATHWAY: Apoptosis inducer -- RESEARCH AREA: Cell death