NQDI-1
ASK1 inhibitor / Potent and selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1), Ki = 500 nM.1 Promotes survival of induced pluripotent stem cells.2 Improves neurological function after intracerebral hemorrhage in a mouse model.3 A highly useful inhibitor for probing the involvement of ASK1 in cellular physiology.4,5
Biochemicals & reagents
175026-96-7
1) Volynets et al. (2011), Identification of 2H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1); J. Med. Chem., 54 2680 2) Nomura et al. (2013), An ASK1-p38 signaling pathway mediates hydrogen peroxide-induced toxicity in NG108-15 neuronal cells; Neurosci. Lett., 549 163 3) Chen et al. (2019), The MC4 receptor agonist RO27-3225 inhibits NLRP1-dependent neuronal pyroptosis via the ASK1/JNK/p38 MAPK pathway in a mouse model of intracerebral haemorrhage; Br. J. Pharmacol., 176 1341 4) Ma et al. (2019), Low glucose and metformin-induced apoptosis of human ovarian cancer cells is connected to ASK1 via mitochondrial and endoplasmic reticulum stress associated pathways; J. Exp. Clin. Cancer Res., 38 77 5) Feng et al. (2018), Dual function of peroxiredoxin I in lipopolysaccharide-induced osteoblast apoptosis via reactive oxygen species and the apoptosis signal-regulating kinase 1 signaling pathway; Cell Death Discov., 4 47
-20°C
TARGET: Kinase -- PATHWAY: JNK pathway; Redox; Apoptosis inhibitor -- RESEARCH AREA: Stem cells; Cell death; Neuroscience; Oxidative stress -- DISEASE AREA: Neurodegeneration; Ischemia