CBR-470-1

Name: CBR-470-1
Brand: Focus Biomolecules
SKU: 10-4680-01
Price: 65 GBP
Availability: InStock

Supplier:

Focus Biomolecules

Catalogue number:

10-4680-01

Size:

5 mg

Product is available in:

$65.00

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NRF2 signaling activator / Activator of NRF2 signaling (EC50 ~ 1 µM cellular ARE-LUC assay).1 It inhibits phosphoglycerate kinase 1 leading to a build-up of methylglyoxal which inactivates KEAP1. It protected SH-SY5Y neuronal cells from MPP+ induced oxidative injury via activation of NRF2 signaling.2

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Product Type:

Biochemicals & reagents

CAS Number:

2416095-06-0

Reference:

1 Bollong et al. (2018) A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling; Nature 562 600 2 Zheng et al. (2020) PGK1 inhibitor CBR-470-1 protects neuronal cells from MPP+; Aging (Albany NY) 12 13388

Storage Temperature:

-20°C

Additional Information:

TARGET: Kinase -- PATHWAY: Mitochondrial function; Transcription -- RESEARCH AREA: Oxidative stress; Neuroscience; Immunology -- DISEASE AREA: Neurodegeneration; Cancer