SC-514
Supplier:
Catalogue number:
10-1054-01
Size:
10 mg
Product is available in:
IKK-2 inhibitor / Reversible, competitive inhibitor of IKK2 (IC50 = 11.2 µM). Has not been demonstrated to inhibit other IKK isoforms, or other kinases. Displays dose-dependent inhibition of the transcription of NK-κB dependent genes in cell culture1.
Product Type:
Biochemicals & reagents
CAS Number:
354812-17-2
Reference:
1) Kishore et al. (2003), A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts; J. Biol. Chem., 278 32861
Storage Temperature:
RT
Additional Information:
TARGET: Kinase -- PATHWAY: NFkappaB; Cytokine -- RESEARCH AREA: Oxidative stress; Immunology -- DISEASE AREA: Inflammation; OsteoporosisKidney disease; Hypertension