AR-A 014418
Supplier:
Catalogue number:
10-1195-02
Size:
25 mg
Product is available in:
GSK-3 inhibitor / Selective glycogen synthase kinase 3 (GSK-3) inhibitor, IC50 = 104 nM. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices. Anti-inflammatory activity. Cell permeable. Active in rodent models.
Product Type:
Biochemicals & reagents
CAS Number:
487021-52-3
Reference:
1) Bhat et al. (2003), Structural insights and biological effects of glycongen synthase kinase 3-specific inhibitor AR-A014418; J. Biol. Chem., 278 45937 2) Ramirez et al. (2010), Inhibition of glycogen synthase kinase 3beat (GSK3beta) decreases inflammatory responses in brain endothelial cells; Am. J. Pathol., 176 881
Storage Temperature:
-20°C
Additional Information:
TARGET: Kinase -- PATHWAY: Carbohydrate metabolism -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Inflammation; Neurodegeneration