N-Acetyl-L-cysteine
Antioxidant / A thiol-containing antioxidant.1 N-Acetyl-L-cysteine acts as a scavenger of reactive oxygen species (ROS) and is commonly used to decrease oxidative stress in various models.2 Inhibits ROS-dependent apoptosis.3 Displays protective effects in various disease models including renal ischemia/reperfusion injury4, hepatic failure5 and others. Has been shown to interfere with and antagonize the activity of proteasome inhibitors.6
Biochemicals & reagents
616-91-1
N-Acetylcysteine; NAC; NSC-111180
1 Merck Index 14 88 2 Mlejnek et al. (2022), Direct Interaction between N-Acetylcysteine and Cytotoxic Electrophile – An Overlooked In Vitro Mechanism of Protection; Antioxidants (Basel), 11 1485 3 Curtin et al. (2002), Regulation and measurement of oxidative stress in apoptosis; J. Immunol. Methods, 265 49 4 Sehirli et al. (2003), Protective effect of N-acetylcysteine on renal ischemia/reperfusion injury in the rat; J. Nephrol. 16 75 5 Ritter et al. (2004), Protective effect of N-acetylcysteine and deferoxamine on carbon tetrachloride-induced hepatic failure in rats; Crit. Care Med. 32 2079 6 Halasi et al. (2033), ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors; Biochem. J. 454 201
-20°C
TARGET: Antioxidant -- PATHWAY: Redox -- RESEARCH AREA: Neuroscience; Oxidative stress -- DISEASE AREA: Inflammation; Mood disordersIschemia; Liver disease