SR1078
ROR agonist / Agonist of the orphan nuclear receptors RORα and RORγ.1 It attenuated intrapancreatic pathological changes in mouse models of chronic pancreatitis via restoration of the circadian stabilizing loop.2 SR1078 stimulation of RORα restored clock protein BMAL1 expression and oscillation and blocked MYCN-mediated neuroblastoma growth.3 It reduced repetitive behavior is a mouse model of autism suggesting a potential therapeutic pathway for the disorder.4 SR1078 treatment lead to an increase in p53 levels and increased apoptosis in HepG2 cells.5
Biochemicals & reagents
1246525-60-9
1) Wang et al. (2010), Identification of SR1078, a synthetic agonist for the orphan nuclear receptors ROR? and ROR?; ACS Chem. Biol. 5 1029 2) Jiang et al. (2022), The pancreatic clock is a key determinant of pancreatic fibrosis progression and exocrine dysfunction; Sci. Transl. Med. 14 eabn3586 3) Moreno-Smith et al. (2021), Restoration of the molecular clock is tumor suppressive in neuroblastoma; Nat. Commun. 12 4006 4) Wang et al. (2016), Therapeutic Effect of a Synthetic ROR?/? Agonist in an Animal Model of Autism; ACS Chem. Neurosci. 7 143 5) Wang et al. (2012), Regulation of p53 Stability and Apoptosis by an ROR Agonist; PLoS One 7 e34921
-20°C
TARGET: Retinoid receptor and related; Transcription factor -- PATHWAY: Transcription; Fatty acid metabolism -- RESEARCH AREA: Circadian clock; Immunology -- DISEASE AREA: Cancer