Honokiol
SIRT3 activator / Honokiol is a natural product that acts as a SIRT3 activator. It increases mitochondrial oxygen consumption and reduces ROS production in wild type but not SIRT3-KO cells.1 It reversed cardiac hypertrophy in mice1 and rescued myocardial and mitochondrial energetics in type 2 diabetic rats2. It was shown to increase SIRT3 expression in the hippocampus and attenuated surgery-induced memory loss, neuronal apoptosis, neuroinflammation and oxidative damage.3 It increases expression of adipocyte gene markers, gene-involved lipolysis and glucose transport and in general, promotes insulin sensitivity.4
Biochemicals & reagents
35354-74-6
NSC-293100
1. Pillai et al. (2015), Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial SIRT3; Nat. Commun. 6 6656 2. Kerr et al. (2020), Rescue of myocardial dysfunction in diabetes through the correction of mitochondrial hyperacetylation by honokiol; JCI Insight 5 e140326 3. Ye et al. (2019), SIRT3 activator honokiol ameliorates surgery/anesthesia-induced cognitive decline in mice through anti-oxidative stress and anti-inflammatory in hippocampus; CNS Neurosci. 25 355 4. Lee et al. (2022), Sirt3 Pharmacologically Promotes Insulin Sensitivity through PI3/AKT/mTOR and Their Downstream Pathway in Adipocytes; Int. J. Mol. Sci. 23 3740
-20°C
TARGET: Protein deacetylase; Transcription factor -- PATHWAY: Mitochondrial function; NFkappaB; AKT; Cytokine; Transcription; Post-translational modification -- RESEARCH AREA: Epigenetics; Neuroscience; Oxidative stress; Angiogenesis -- DISEASE AREA: Neurodegeneration; CancerInflammation; Diabetes; Obesity