Ketanserin tartrate
Serotonin 5-HT2A antagonist / Ketanserin tartrate is a selective serotonin 5-HT2A receptor antagonist (IC50 = 6.3 nM).1 Also exhibits significant selectivity for the human 5-HT1Dα receptor.2 Was shown to be effective for the treatment of hypertension following coronary artery surgery.3 Has been used to disrupt the hallucinogenic effects of psilocybin and to explore cognitive effects of the 5-HT2A receptor.4
Biochemicals & reagents
83846-83-7
R41468
1 Leysen et al. (1981), Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptors; Life Sci. 28 1015 2 Zgombick et al. (1995), Ketanserin and ritanserin discriminate between recombinant human 5-HT1D alpha and 5-HT1D beta receptor subtypes; Eur. J. Pharmacol. 291 9 3 Vandenbroucke et al. (1994), Use of ketanserin in the treatment of hypertension following coronary artery surgery; J. Cardiothorac. Vasc. Anesth. 8 P324 4 Quednow et al. (2012), Psilocybin-induced deficits in automatic and controlled inhibition are attenuated by ketanserin in healthy human volunteers; Neuropsychopharmacology 37 630
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TARGET: Monoamine receptor; Serotonin -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Hypertension; Addiction