Oxaprozin
NFκB inhibitor / Oxaprozin is a clinically useful non-steroidal anti-inflammatory drug.1 In addition to typical NSAID COX inhibition, Oxaprozin may also exert anti-inflammatory effects via inhibition of the Akt/IKK/NF-kappaβ pathway.2 The compound is capable of inhibiting both anandamide hydrolase in neurons (IC50= 85 µmol/l), with consequent potent analgesic activity, and NF-kappaB activation in inflammatory cells (IC50 = 50 µmol/l).3
Biochemicals & reagents
21256-18-8
1) Merck 14:6924 / 2) Ottonello et al. (2009), Delayed apoptosis of human monocytes exposed to immune complexes is reversed by oxaprozin: role of the Akt/IkappaB kinase/nuclear factor kappaB pathway; Br.J. Pharmacol., 157 294 / 3) Dallegri et al. (2005), A review of the emerging profile of the anti-inflammatory drug oxaprozin.; Expert Opin.Pharmacother., 6 777
RT
TARGET: COX (Cyclooxygenase); Serine hydrolase -- PATHWAY: NFkappaB; AKT; Cytokine -- RESEARCH AREA: Neuroscience; Immunology -- DISEASE AREA: Inflammation; Pain