SL-01
p53/mdm2 inhibitor / Inhibits the p53-MDM2 interation (20 μM).1 Alkylates one catalytic histidine residue (His-397) participating in the charge-relay system of carboxypeptidase Y.2 Has also been shown to inhibit bovine chymotrypsin A-γ. A potent inhibitor of the severe acute respiratory syndrome coronavirus (SARS-CoV) main protease (Mpro), Ki=306 nM.3
Biochemicals & reagents
26049-94-5
ZPCK
1 Li et al. (2011), A cell-based high-throughput assay for the screening of small-molecule inhibitors of p53-MDM2 interaction.; J. Biomol. Screening, 16 450 2 Jung et al. (1995), Identification of the catalytic histidine residue participating in the charge-relay system of carboxypeptidase Y.; Protein Sci., 4 2433 3 Bacha et al. (2004), Identification of novel inhibitors of the SARS coronavirus main protease 3CLPro.; Biochemistry, 43 4906
-20°C
TARGET: Transcription factor; Protease -- PATHWAY: Cell cycle; p53; Transcription -- DISEASE AREA: Cancer; Infectious disease