MHY1485
mTOR activator / mTOR activator. Suppresses autophagy by inhibiting the fusion of autophagosomes with lysosomes leading to the accumulation of enlarged autophagosomes.1 Increases ovarian follicle development.2 Displays cellular protective effects from cytotoxic doses of dexamethasone3 or UV radiation4. A useful tool for probing the cellular role of mTOR.5 Cell permeable.
Biochemicals & reagents
326914-06-1
1) Choy et al. (2012), Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion; PLoS One, 7(8) e43418 2) Cheng et al. (2015), Promotion of ovarian follicle growth following mTOR activation: synergistic effects of AKT stimulators; PLoS One, 10(2) e0117769 3) Zhao et al. (2016), MHY1485 activates mTOR and protects osteoblasts from dexamethasone; Biochem. Biophys. Res. Commun., 481 212 4) Yang et al. (2017), MHY1485 ameliorates UV-induced skin cell damages via activating mTOR-Nrf2 signaling Oncotarget, 8 12775 5) Li and Siragy (2015), (Pro)renin receptor regulates autophagy and apoptosis in podocytes exposed to high glucose; J. Physiol. Endocrinol. Metab., 309 E302
RT
TARGET: Kinase; Lysosome -- PATHWAY: mTOR; Autophagy; Degradation -- RESEARCH AREA: Cell death; Vesicles -- DISEASE AREA: Cancer