GSK872
Necroptosis inhibitor / RIP3 inhibitor / GSK872 is a potent (IC50 = 1.8nM domain binding; IC50 = 1.3 nM kinase activity) and selective inhibitor of receptor interacting protein 3 (RIP3).1 It is able to prevent necroptosis, virus-induced necrosis, and TLR3-induced necrosis.1,2 GSK872 can induce Caspase8-mediated apoptosis at higher concentrations (e.g.3 µM).2
Biochemicals & reagents
1346546-69-7
GSK2399872A; GSK’872
1) Kaiser et al. (2013) Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL; J.Biol.Chem. 288 31279 2) Mandal et al. (2014) RIP3 induces apoptosis independent of pro-necrotic kinase activity; Mol.Cell 56 481
-20°C
TARGET: Kinase; Inflammasome -- PATHWAY: Necroptosis; Necrosis; Apoptosis inducer; TLR signaling; JNK pathway; Ferroptosis -- RESEARCH AREA: Cell death; Oxidative stress; Immunology; Neuroscience -- DISEASE AREA: Infectious disease; IschemiaInflammation