Nigericin Na
Induces rapid intracellular acidification / Polyether ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria. Induces apoptosis resulting from intracellular acidification. Ion selectivity is K+> Rb+> Cs+>>Na+. Cell permeable.
Biochemicals & reagents
28643-80-3
Antibiotic K178; Antibiotic X-464; Azalomycin M; PolyetherinA
1) Akhmedov et al. (2010), Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells; FASEB J., 24 4613 / 2) Gong et al. (2010), chemical probing reveals insights into the signaling mechanism of inflammasome activation; Cell Res., 20 1289
-20°C
TARGET: Ionophore; Inflammasome -- PATHWAY: Mitochondrial function; Apoptosis inducer -- RESEARCH AREA: Cell death -- DISEASE AREA: Inflammation; Infectious disease