Muscone
Cardioprotective and neuroprotective agent / Muscone (541-91-3) is a macrocyclic ketone found naturally in a glandular secretion of the musk deer which acts at human odorant receptor OR5AN1 and is used in perfumes.1 It suppresses inflammatory responses and neuronal damage in various models including a rat model of cervical spondylotic myelopathy2 and relieves inflammatory pain acting via the NOX4/JAK2-STAT3 and NLRP3 inflammasome pathway3. In the cardiovascular system it alleviates myocardial ischemia-reperfusion injury4 and improves cardiac function in mice after myocardial infarction5 via enhancement of angiogenesis6.
Biochemicals & reagents
541-91-3
1 Ahmed et al. (2018), Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds; Proc. Acad. Natl. Sci. USA 115 E3950 2 Zhou et al. (2020), Muscone suppresses inflammatory responses and neuronal damage in a rat model of cervical spondylotic myelopathy by regulating Drp1-dependent mitochondrial fission; J. Neurochem. 155 154 3 Yu et al. (2020), Muscone relieves inflammatory pain by inhibiting microglial activation-mediated inflammatory response via abrogation of the NOX4/JAK2-STAT3 pathway and NLRP3 inflammasome; Int. Immumopharmacol. 82 106355 4 Wei et al. (2021), Muscone alleviates myocardial ischemia-reperfusion injury via inhibition of oxidative stress and enhancement of SIRT3; J. Biol. Regul. Homeost. Agents 35 85 5 Du et al. (2018), Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-κB and NLRP3 inflammasome; Am. J. Transl. Res. 17 103 6 Du et al. (2018), Hypoxia-Inducible Factor 1 alpha (HIF-1α)/Vascular Endothelial Growth Factor (VEGF) Pathway Participates in Angiogenesis of Myocardial Infarction in Muscone-Treated Mice: Preliminary Study; Med. Sci. Monit. 24 8870
-20°C
TARGET: Cytochrome/MDR; Inflammasome -- PATHWAY: Cytokine; Mitochondrial function; Wnt; JAK/STAT -- RESEARCH AREA: Neuroscience; Immunology; Stem cells; Oxidative stress -- DISEASE AREA: Inflammation; IschemiaHeart disease; Neurodegeneration; Cancer