Probucol
Antioxidant hypercholesterolemic agent / Probucol (23288-49-5) is a unique antilipidemic drug which inhibits the oxidation of LDL cholesterol preventing the genesis of macrophage-derived foam cells and thus suppressing the formation of atherosclerotic vascular lesions.1 It inhibits ABCA1-mediated cholesterol efflux without influencing scavenger receptor (class B type 1)-mediated efflux.2 It enhances mitophagy and improves survival, locomotor function and dopaminergic neuron loss in zebrafish and fly models of mitochondrial damage.3 It attenuates NF-kB/NLRP3 signaling and augments Nrf-2-mediated antioxidant defense in nerve injury models.4 Improves learning and memory in aging mice.5 It protects neuronal cells against peroxide-induced damage and directly activates glutathione peroxidase-1.6
Biochemicals & reagents
23288-49-5
DH-581
1 Yamamoto et al. (2013), A unique antilipidemic drug – Probucol; J. Atheroscler. Thromb. 15 304 2 Favari et al. (2004), Probucol inhibits ABCA1-mediated cellular lipid efflux; Arterioscler. Thromb. Vasc. Biol. 24 2345 3 Moskal et al. (2023), An AI-guided screen identifies probucol as an enhancer of mitophagy through modulation of lipid droplets; PLoS Biol. 21 e3001977 4 Derangula et al. (2022), Probucol attenuates NF-kB/NLRP3 signaling and augments Nrf-1 mediated antioxidant defence in nerve injury induced neuropathic pain; Immunopharmacol 102 108397 5 Xie et al. (2021), Effects and mechanisms of probucol on aging-related hippocampus-dependent cognitive impairment; Biomed. Pharmacother. 144 112266 6 Santos et al. (2020), Probucol Protects Neuronal Cells Against Peroxide-Induced Damage and Directly Activates Glutathione Peroxidase-1; Mol. Neurobiol. 57 3245
RT
TARGET: Antioxidant; Inflammasome -- PATHWAY: Cholesterol metabolism; Mitophagy; Mitochondrial function -- RESEARCH AREA: Oxidative stress; Neuroscience -- DISEASE AREA: Neurodegeneration; AtherosclerosisHeart disease; Inflammation