JZL-184
MAG lipase inhibitor / Inhibits MAG lipase (IC50=8 nM) selectively over FAAH. Irreversible. Cell permeable.
Biochemicals & reagents
1101854-58-3
1) Long et al. (2009), Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects; Nat. Chem. Biol., 5 37 / 2) Pan et al. (2009), Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxyl)methyl)piperidine-1-carboxylate (JZL 184) Enhances retrograde endocannabinoid signaling; J. Pharmacol. Exp. Ther., 331 591 / 3) Kinsey et al. (2009), Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain; J. Pharmacol. Exp. Ther., 330 902
RT
TARGET: Lipase; GPCR -- PATHWAY: Lipid signaling -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Ischemia; InflammationPain; Neurodegeneration; Mood disorders