Stavudine
HIV reverse transcriptase inhibitor / Thymidine derivative that acts as an HIV nucleoside reverse transcriptase inhibitor (NRTI) (EC50 = 8.8 nM for HIV-1 replication in human PBMCs).1,2 Down-modulates P2X7-mediated NLRP3 inflammasome activation independent of reverse transcriptase inhibition.3 Reduces production of IL-18 and caspase-1 and stimulates Aβ-induced autophagy in macrophages.4
Biochemicals & reagents
3056-17-5
BMY 27857; d4T
1 T-S Lin et al. (1987), Potent and selective in vitro activity of 3’-deoxythymidin-2’-ene (3’-deoxy-2’,3’-didehydrothymidine) against human immunodeficiency virus; Biochem. Pharmacol., 36 2713 2 Baba et al. (1987), Both 2’,3’-dideoxythymidine and its 2’,3’-unsaturated derivative (2’,3’-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro; Biochem. Biophys. Res. Commun., 142 128 3 Fowler et al. (2014), Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity; Science, 346 1000 4 La Rosa et al. (2019), Stavudine Reduces NLRP3 Inflammasome Activation and Modulates Amyloid-ß Autophagy; J. Alzheimer’s Dis., 72 401
-20°C
TARGET: Inflammasome; DNA -- PATHWAY: Autophagy; Cytokine -- RESEARCH AREA: Immunology; Neuroscience; Cell death -- DISEASE AREA: Neurodegeneration; Infectious diseaseInflammation