Lamivudine
Reverse transcriptase inhibitor / A nucleoside analog reverse transcriptase inhibitor1. A potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2)2. Displays anti-inflammatory effects, including reduction of inflammasome-related proteins P2X7 and NLRP3, in retinal microvascular endothelial cells treated with high glucose and LPS as well as in streptozotocin diabetic mice3. Disrupts repeat element life cycle in colorectal cancer4.
Biochemicals & reagents
134678-17-4
(-)-BCH-189; 3TC
1. EJ Arts and MA Wainberg Antimicrob. Agents Chemother. 1996 40:527 2. JA Coates et al. Antimicrob. Agents Chemother. 1992 36:733 3. H Kong et al. Cell Death Dis. 2022 13:336 4. M Rajukar et al. Cancer Discov. 2022 Mar 23:candisc.1117.2021 Online ahead of print.
-20°C
TARGET: Inflammasome; DNA -- DISEASE AREA: Cancer; Infectious diseaseInflammation