NSC33994
JAK2 inhibitor / A remarkably potent and selective JAK2 inhibitor (IC50 = 60 nM). Displays no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM1. Suppresses JAK2-V617F-mediated human pathological cell growth in vitro and in vivo2 and is concomitant with the disruption of intracellular vimentin filaments3. Reduces the tumorigenic potential of T98G glioblastoma cells in vitro and in vivo4.
Biochemicals & reagents
82058-16-0
G6
1) Kiss et al. (2009), Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening; Bioorg Med. Chem. Lett., 19 3598 2) Kirabo et al. (2011), The stilbenoid tyrosine kinase inhibitor, G6, suppresses Jak2-V617F-mediated human pathological cell growth in vitro and in vivo J. Biol. Chem., 286 4280 3) Majumder et al. (2011), Cell death induced by the Jak2 inhibitor, G6, correlates with cleavage of vimentin filaments; Biochemistry, 50 7774 4) Baskin et al. (2014), The Jak2 small molecule inhibitor, G6, reduces the tumorigenic potential of T98G glipblastoma cells in vitro and in vivo; PLoS One, 9(8) e105568
-20°C
TARGET: Kinase; Cytoskeleton -- PATHWAY: JAK/STAT -- DISEASE AREA: Cancer