Sulindac Sulfide
NFκB inhibitor / Active metabolite of cyclooxygenase inhibitor sulindac.1 Strongly inhibits Ras induced malignant transformation and Ras/Raf dependent transactivation.2 Induces apoptosis in cancer cells via PDE5 inhibition.3,4
Biochemicals & reagents
49627-27-2
1) Duggan et al. (1977) Identification of the biologically active form of sulindac. J.Pharmacol.Exp.Ther.. 201 8 / 2) Herrmann et al. (2000) Sulindac sulfide inhibits Ras signaling Nature 17 1769 / 3) Tinsley et al. (2010) Colon tumor cell growth inhibitory activity of sulindac sulfide and other NSAIDS is associated with PDE5 inhibition Cancer Prev.Res. 3 1303 / 4) Tinsley et al. (2011) Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin mediated transcription in human breast tumor cells Cancer Prev.Res. 4 1275
RT
TARGET: PDE (Phosphodiesterase); COX (Cyclooxygenase) -- PATHWAY: NFkappaB; Apoptosis inducer; Cytokine; TNF -- RESEARCH AREA: Cell death -- DISEASE AREA: Cancer; Inflammation