Compound 115-7c
HSP70 modulator / Acts as an artificial co-chaperone for HSP701. The activity of compound 115-7c mirrors those of HSP40 stimulating the ATPase and protein-folding activities of prokaryotic HSP70. Increases tau levels in cell lines overexpressing tau2. Induces solubilization of polyglutamine and exacerbates polyQ-mediated toxicity3,4. An important probe for understanding HSP70 functions4
Biochemicals & reagents
908074-72-6
SW02
1) Wisen et al. (2010), Binding of a small molecule a the protein-protein interface regulates the chaperone activity of hsp70-hsp40; ACS Chem. Biol., 5 611 2) Jinwal et al. (2010), Hsp70 ATPase Modulators as Therapeutics for Alzheimer’s and other Neurodegenerative Diseases; Mol. Cell Pharmacol., 2 43 3) Chafekar et al. (2012), Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation; ACS Chem. Biol., 7 1556 4) Walter et al. (2011), Ordered assembly of heat shock proteins Hsp26, Hsp70, Hsp90, and Hsp104, on expanded polyglutamine fragments revelaed by chemical probes; J. Biol. Chem., 286 40486
-20°C
TARGET: HSP (Heat shock protein); Chaperone -- PATHWAY: Autophagy -- RESEARCH AREA: Neuroscience; Ubiquitin/Proteasome; Cell death; Cellular stress -- DISEASE AREA: Neurodegeneration