Nicotinamide
SIRT1 inhibitor/essential nutrient / Essential nutrient (amide form of Vitamin B3) that is incorporated into cofactors NADH/NAD+, important for ATP production and other key metabolic functions.1 Transiently inhibits SIRT1/SIRT3 through feedback inhibition (IC50 ~ 50 µM)2, but is quickly converted to NAD+ in cells3. Also inhibits certain kinases (e.g. ROCK and CK1), making it a regulator of hPSC pluripotency, survival, and differentiation.4 Inhibits differentiation and enhances functionality of hematopoietic stem/progenitor cells (HSPCs).5
Biochemicals & reagents
98-92-0
Nicotinic acid amide; Niacinamide; Vitamin B3; NAM
Zapata-Pérez et al. (2021), NAD+ homeostasis in human health and disease; EMBO Mol. Med., 13 e13943 Guan et al. (2014), Mechanism of inhibition of the human sirtuin enzyme SIRT3 by nicotinamide: computational and experimental studies; PLoS One, 9 e107729 Hwang and Song (2017), Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells; Mol. Life Sci., 74 3347 Meng et al. (2018), Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells; Stem Cell Reports, 11 1347 Horwitz et al. (2014), Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment; Clin. Invest., 124 3121
RT
TARGET: Protein deacetylase; Kinase; Energy production -- PATHWAY: Posttranslational modification; NAD, NADP pathways; DNA damage -- RESEARCH AREA: Epigenetics; Stem cells -- DISEASE AREA: Cancer