TET 830 modified/T-helper epitope from tetanus toxoid - AQYIKANSKFIGITEL

TET 830 modified/T-helper epitope from tetanus toxoid – AQYIKANSKFIGITEL: Tetanus toxoid is the altered form of tetanus toxin (UniProt: P04958), used in vaccines to prevent tetanus infection. Tetanus toxin acts as a zinc endopeptidase, that cleaves the ’76-Gln-|-Phe-77′ bond within synaptobrevin-2, thereby impeding the release of neurotransmitters. Among the 1315 amino acids composing tetanus toxoid, researchers identified the fragment (830-844) QYIKANSKFIGITEL (see #SB305 – TET 830 peptide) that binds to MHC class II molecules as a nonspecific vaccine adjuvant to induce and increase the helper T-cell response. Later addition of Alanine at the N-terminal of the sequence turned the peptide into a universal human tetanus toxin T-cell epitope that can be used as helper peptide in vaccinations.