Tetanus Toxin (830-844) peptide – QYIKANSKFIGITEL

TET 830 – QYIKANSKFIGITEL peptide: Tetanus toxoid is the altered form of tetanus toxin (UniProt: P04958), used in vaccines to prevent tetanus infection. Tetanus toxin acts as a zinc endopeptidase, that cleaves the ’76-Gln-|-Phe-77′ bond within synaptobrevin-2, thereby impeding the release of neurotransmitters. Among the 1315 amino acids composing tetanus toxoid, researchers identified the fragment (830-844) QYIKANSKFIGITE, also known as « tetanus toxin P2 protein ». This fragment displays antigenic properties resembling the neurotoxin released by Clostridium tetani. Hence, it can function as an appropriate epitope for CD4+ T-cells, stimulating the release of IFN-γ, that promotes macrophage activity and coordinates lymphocyte-endothelium interactions.