2-Deoxy-D-Glucose
Biologically active glucose analog / 2-Deoxy-D-glucose (2-DG) is a synthetic glucose analog with extensive biological effects. It is commonly thought of as an inhibitor of glycolysis, but its metabolic effects are wide-ranging. 2-DG competitively inhibits glucose uptake via its metabolite 2-Deoxy-D-glucose-6-phosphate, which inhibits hexokinase and phosphoglucose-isomerase leading to decreased ATP production, cell cycle blockage, decreased cell growth and ultimately cell death.1,2
Biochemicals & reagents
154-17-6
2-DG
1) Ralser et al., (2008), A catabolic blockade does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth; Proc.Natl.Acad.Sci. USA 105 17807 2) Giammarioli et al. (2012), Differential effects of the glycolysis inhibitor 2-deoxy-D-glucose on the activity of pro-apoptotic agents in metastatic melanoma cells; Int.J.Cancer 131 e337
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TARGET: UPR (Unfolded protein response); Glycosylation -- PATHWAY: Cell cycle; Glucose metabolism; Warburg effect; Autophagy; Cytokine -- RESEARCH AREA: Cell death; Cellular stress; Neuroscience -- DISEASE AREA: Diabetes; NeurodegenerationKidney disease; Cancer; Inflammation