MitTx
MitTx toxin is a ASIC1a/1b agonist. MitTx is a peptide isolated from the Venom of the Texas coral snake Micrurus tener tener. MitTx is a selective agonist for acid-sensing ion channels 1 (ASIC1s) and produces a similar effect than pH drops. MitTx activates both ASIC1a & ASIC1b with a higher selectivity for ASIC1a (EC50 = 9.4 nM) compared to the ASIC1b (EC50= 23 nM). MitTx also demonstrates an activity for ASIC3 with a lower potency (EC50=830 nM).
Peptides & proteins
doi: 10.1038/nature10607 doi: 10.1016/j.cell.2014.01.011
AA Sequence: MitTx-α subunit: QIRPAFCYEDPPFFQKCGAFVDSYYFNRSRITCVHFFYGQCDVNQNHFTTMSECNRVCHG Disulfide bonds between: Cys31-Cys82, Cys41-Cys65, Cys57-Cys78 MitTx-β subunit: NLNQFRLMIKCTNDRVWADFVDYGCYCVARDSNTPVDDLDRCCQAQKQCYDEAVKVHGCKPL VMFYSFECRYLASDLDCSGNNTKCRNFVCNCDRTATLCILTATYNRNNHKIDPSRCQ Disulfide bonds between: Cys41-Cys100, Cys55-Cys148, Cys57-Cys73, Cys72-Cys130, Cys79-Cys123, Cys89-Cys116, Cys109-Cys121