Ovotransferrin (328-332)

Ovotransferrin 328-332, also called Conalbumin 328-332, is a part of the egg white albumen. Anti-hypertensive activity: RVPSL peptide has been described to have a protective activity on the blood pressure by inhibiting the Angiotensin-Converting Enzyme (ACE). Ovotransferrin 328-332 peptide would be a serious drug candidate, as powerful as current drugs and without side effects. Involvement in Alzheimer’s disease: This peptide fragment demonstrated recently an activity against Acetylcholinesterase (AchE), which is implicated in Alzheimer’s diseases. Actually, a deficiency in the brain levels of acetylcholine is seen as key step in the pathogenesis of Alzheimer disease. Otherwise, Ovostransferrin 328-332 seems to be involved in a possible inhibition of beta-site APP clieaving enzyme 1 (BACE1), which is one of the most promising new therapeutic approaches for Alzheimer’s diseases. Indeed, this receptor induce the formation of Amyloid Beta, a typical peptide from Alzheimer’s diseases.