TRP2

This peptide is derived from tyrosinase-related protein 2 (TRP2) residues 180-188. TRP2, also named L-dopachrome tautomerase, H-2KB or DCT, belongs to the melanocyte differentiation antigens and has been implicated as a target for immunotherapy of human as well as murine melanoma. Studies show that this TRP2 derived peptide can bind to mouse and human MHC class Imolecules. Immunization with TRP2 peptide loaded dendritic cells (DCs) results in effective induction of antitumor immunity