TRAP-6

Thrombin Receptor Activator Peptide 6 (TRAP-6), also called Selective Protease-Activated Receptor 1 (PAR-1) Agonist, is an hexapeptide fragment of the thrombin receptor (residues 42-47). TRAP-6 has been shown to selectively activate PAR1 and thus induce platelet aggregation (EC50 = 0.8 μM). Its usefulness has therefore been demonstrated in cardiovascular study models and in hematology. Biologically, TRAP-6 is the N-terminal fragment of the thrombin receptor resulting from its cleavage by thrombin. This peptide therefore offers a cost-effective solution for the study of in-vitro cardiovascular models. What is PAR-1 ? Proteinase-activated receptor 1 (PAR1), also known as coagulation factor II (thrombin) receptor, is a G protein-coupled receptor and is involved in the regulation of thrombotic response. It is highly expressed in platelets and endothelial cells Other Applications ? Therefore, this peptide was used to activate platelets in vitro but it also demonstrated a protective action on astrocytes, which is associated with hypoglycemia. Thus, some research has focused on the use of TRAP-6 peptide to study the pathways that regulate hypoglycemia. Others have also been interested in TRAP-6 because of its stimulating action on certain transcription regulators, notably the yes-associated protein (YAP).