Bafilomycin A1
Vacuolar H+ ATPase inhibitor / Macrolide antibiotic derived from Streptomyces griseus that is a potent and selective inhibitor of vacuolar H+-ATPases (IC50 = 0.6 – 1.5 nM).1,2 Inhibits autophagy via disruption of fusion between autophagosomes and lysosomes.3
Biochemicals & reagents
88899-55-2
1) Werner et al. (1984) Metabolic products of microorganisms. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity. J.Antibiot. 37 110 / 2) Drose and Altendorf (1997) Bafilomycins and concanamycins as inhibitors of V-ATPase and P-ATPase J.Exp.Biol. 200 1 / 3) Yamamoto et al. (1998) Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells Cell Struct.Func. 23 33
-20°C
TARGET: ATPase; Lysosome; Antibiotic -- PATHWAY: Intracellular transport; Autophagy; Cholesterol metabolism; Senescence -- RESEARCH AREA: Cell death; Vesicles -- DISEASE AREA: Infectious disease