Auranofin
IKK inhibitor / Disease-modifying antirheumatic drug (DMARD) , It is a potent inhibitor of selenoenzyme thioredoxin reductase and IκB kinase (IKK) by modifying Cys-179. Auranofin is an efficient inducer of mitochondrial membrane permeability transition pore in the presence of calcium ions.
Biochemicals & reagents
34031-32-8
SKF-39162
1) Columbo et al. (1990), Modulation of mediator release from human basophils and pulmonary mast cells and macrophages by auranofin; Biochem. Pharmacol., 39 285. / 2) Rigobello et al. (2002), Induction of mitochondrial permeability transition by auranofin, a gold(I)-phosphine derivative; Br.J. Pharmacol., 136 1162 / 3) Merck 14 878
RT
TARGET: Kinase; DUB (Deubiquitinating enzyme) -- PATHWAY: Mitochondrial function; NFkappaB; Pyroptosis; Degradation; Cytokine; Redox -- RESEARCH AREA: Neuroscience; Oxidative stress; Cell death; Ubiquitin/Proteasome -- DISEASE AREA: Inflammation; Infectious diseaseCancer; Heart disease; Neurodegeneration