Sigma receptor agonist / DTG is an agonist of the sigma (σ) receptor1 with roughly equal potency against both subtypes (σ1 and σ2 IC50’s ~ 30nM)2.
Product Type:
Biochemicals & reagents
CAS Number:
97-39-2
Reference:
1) Weber et al. (1986), 1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs; Proc.Natl.Acad.Sci.USA, 83 8784 2) Scherz et al. (1990), Synthesis and Structure-Activity Relationships of N,N’-Di-o-tolylguanidine Analogues, High-Affinity Ligands for the Haloperidol-Sensitive σ Receptor; J.Med.Chem., 33 2421
Storage Temperature:
RT
Additional Information:
TARGET: ER/Golgi -- PATHWAY: Calcium signaling -- RESEARCH AREA: Neuroscience