Carfilzomib
Proteasome inhibitor / A potent and irreversible proteasome inhibitor.1 Synthetic analog of the microbial product epoxomcin.2 Compared to bortezomib it displays equal potency but greater selectivity for the chymotrypsin-like activity of the proteasome. In cell culture it is more cytotoxic than bortezomib and hematologic tumor cells exhibit greater sensitivity than solid tumor cells. Treatment of cells with carfilzomib results in the accumulation of proteasome substrates and induction of cell cycle arrest and/or apoptosis.3 Effective against multiple myeloma.4 Active in vivo.
Biochemicals & reagents
868540-17-4
PR-171
1) Bennett and Kirk (2008) Development of proteasome inhibitors in oncology and autoimmune diseases; Curr. Opin. Drug Disc. Dev. 11 616 2) Hanada et al. (1992), Epoxomicin, a new antitumor agent of microbial origin; J. Antibiot. (Tokyo), 45 174 3) Demo et al. (2007) Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome; Cancer Res. 67 6383 4) Kuhn et al. (2007), Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma; Blood, 110 3281
-20°C
TARGET: Proteasome -- PATHWAY: Degradation; Cell cycle; Apoptosis inducer; Cytotoxicity -- RESEARCH AREA: Ubiquitin/Proteasome; Cell death; Immunology -- DISEASE AREA: Cancer