Captopril
Angiotensin-converting enzyme inhibitor / Captopril is an angiotensin-converting enzyme (ACE) inhibitor (IC50 = 0.022 μM).1 Also inhibits the bifunctional Zn2+-containing leukotriene A4 hydrolase/aminopeptidase (LTA4 hydrolase) reversibly and competitively (Ki = 6.0 μM for leukotriene B4 formation and Ki = 60 nM for L-lysine-p-nitroanilide).2 Displays vasodilatory and antihypertensive effects in vivo. Clinically useful antihypertensive agent.
Biochemicals & reagents
62571-86-2
1) Cushman et al. (1999), Design of angiotensin converting enzyme inhibitors; Nat.Med. 5 1110 2) Orning et al. (1991), Inhibition of leukotriene A4 hydrolase/aminopeptidase by captopril; J.Biol.Chem. 266 16507
-20°C
TARGET: Protease -- PATHWAY: Lipid signaling -- DISEASE AREA: Hypertension