INK-128
Supplier:
Catalogue number:
10-3362-02
Size:
25 mg
Product is available in:
TORC1/2 inhibitor / A potent and selective, ATP-competitive inhibitor of mTOR kinase, Ki = 1.4 nM.1 Inhibits growth and proliferation of various breast cancer cell lines and human endothelial cells.2
Product Type:
Biochemicals & reagents
CAS Number:
1224844-38-5
Alternative Names:
MLN-0128
Reference:
1) Hsieh et al. (2012), The translational landscape of mTOR signaling steers cancer initiation and metastasis; Nature, 485 55 2) Gokmen-Polar et al. (2012) Investigational drug MLN0128, a novel TORC1/2 inhibitor, demonstrates potent oral antitumor activity in human breast cancer xenograft models; Breast Cancer Res. Treat., 136 673
Storage Temperature:
-20°C
Additional Information:
TARGET: Kinase -- PATHWAY: mTOR; Proliferation; PI3K; Apoptosis inducer -- RESEARCH AREA: Cell death -- DISEASE AREA: Cancer