RIPA-56
Supplier:
Catalogue number:
10-4611-01
Size:
10 mg
Product is available in:
RIP1 kinase inhibitor / RIPA-56 is a potent (IC50 = 13 nM, EC50 = 28nM for HT-29 cells) and selective inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with significant metabolic stability (t1/2 = 128min human liver microsomal stability assay). RIPA-56 showed excellent kinase selectivity and did not inhibit IDO at 200 µM.
Product Type:
Biochemicals & reagents
CAS Number:
1956370-21-0
Reference:
1) Ren et al. (2017), Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome; J.Med.Chem. 60 972
Storage Temperature:
-20°C
Additional Information:
TARGET: Kinase -- PATHWAY: TNF; Cytokine -- DISEASE AREA: Inflammation