H89 · 2HCl
Supplier:
Catalogue number:
10-2144-02
Size:
25 mg
Product is available in:
PKA inhibitor / H-89 is a commonly used inhibitor of protein kinase A (PKA IC50 = 140 nM). Inhibits a variety of other kinases including S6K1 (IC50 = 80 nM), MSK1 (120 nM), ROCK II (270 nM), PKBα (2.6 µM), PKD, PRK2, RSK1 and 2, SGK, AMPK, CHK1 and MAPKAP-K1b (2.8 µM).1,2
Product Type:
Biochemicals & reagents
CAS Number:
127243-85-0
Reference:
1) Lochner and Moolman (2006), The many faces of H89: a review; Cardiovasc. Drugs, 24 261 2) Bain et al. (2007), The selectivity of protein kinase inhibitors: a further update; Biochem.J. 408(Pt3) 297
Storage Temperature:
-20°C
Additional Information:
TARGET: Kinase -- PATHWAY: Calcium signaling; Carbohydrate metabolism -- DISEASE AREA: Diabetes