Niclosamide
STAT3 signaling inhibitor / Reversibly inhibits mTORC1 signaling and stimulates autophagy1. Inhibits activation and nuclear translocation of STAT3 selectively over STAT1 and STAT5. Inhibits transcription of STAT3 target genes and induces cell cycle arrest and apoptosis in cells with constitutively active STAT32.
Biochemicals & reagents
50-65-7
1) Balgi et al. (2009), Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling; PloS One, 4 e7124 2) Ren et al. (2010), Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway; ACS Med. Chem. Lett., 1 454
RT
TARGET: Ionophore; Transcription factor; Ubiquitin ligase -- PATHWAY: Autophagy; Cell cycle; Apoptosis inducer; Mitochondrial function; JAK/STAT; Transcription -- RESEARCH AREA: Cell death; Ubiquitin/Proteasome -- DISEASE AREA: Cancer; ParasitesInflammation; Infectious disease