Valinomycin
Induces loss of mitochondrial membrane potential / Valinomycin is a selective K+ ionophore capable of transporting potassium ions through lipid membranes.1 It can induce apoptosis in cells by causing a rapid loss of mitochondrial membrane potential via potassium efflux.2,3
Biochemicals & reagents
2001-95-8
1) Pressman, (1976) Biological applications of ionophores; Annu.Rev.Biochem. 45 501 / 2) Furlong et al., (1998) Induction of apoptosis by valinomycin: mitochondrial permeability transition causes intracellular acidification Cell Death Diff. 5 214 / 3) Inai et al. (1997) Valinomycin induces apoptosis of ascites hepatoma cells (AH-130) in relation to mitochondrial membrane potential; Cell Struc.Funct. 22 555
-20°C
TARGET: Ionophore; Ubiquitin ligase -- PATHWAY: Apoptosis inducer; Mitochondrial function; Degradation; Autophagy -- RESEARCH AREA: Cell death; Ubiquitin/Proteasome