Valinomycin

Name: Valinomycin
Brand: Focus Biomolecules
SKU: 10-2112-01
Price: 42 GBP
Availability: InStock

Supplier:

Focus Biomolecules

Catalogue number:

10-2112-01

Size:

10 mg

Product is available in:

$42.00

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Induces loss of mitochondrial membrane potential / Valinomycin is a selective K+ ionophore capable of transporting potassium ions through lipid membranes.1 It can induce apoptosis in cells by causing a rapid loss of mitochondrial membrane potential via potassium efflux.2,3

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Product Type:

Biochemicals & reagents

CAS Number:

2001-95-8

Reference:

1) Pressman, (1976) Biological applications of ionophores; Annu.Rev.Biochem. 45 501 / 2) Furlong et al., (1998) Induction of apoptosis by valinomycin: mitochondrial permeability transition causes intracellular acidification Cell Death Diff. 5 214 / 3) Inai et al. (1997) Valinomycin induces apoptosis of ascites hepatoma cells (AH-130) in relation to mitochondrial membrane potential; Cell Struc.Funct. 22 555

Storage Temperature:

-20°C

Additional Information:

TARGET: Ionophore; Ubiquitin ligase -- PATHWAY: Apoptosis inducer; Mitochondrial function; Degradation; Autophagy -- RESEARCH AREA: Cell death; Ubiquitin/Proteasome